Quantitative proteomic and glycoproteomic analysis identifies CLCA1, FBN1, and FGB as potential biomarkers for ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC), a prevalent inflammatory bowel disease (IBD), significantly increases the risk of colorectal cancer with prolonged duration. Current diagnostic approaches for UC rely on clinical symptoms, inflammatory markers, and endoscopic findings. However, these methods often face challenges due to symptom overlap with Crohn's disease (CD) and other gastrointestinal conditions. This highlights a critical need for reliable biomarkers in human body fluids for accurate UC diagnosis and effective therapeutic intervention. To address this, we employed quantitative proteomic and glycoproteomic analysis using liquid chromatography-mass spectrometry on proteins extracted from UC tissues and paracancerous (PCA) tissues. Our comprehensive findings revealed that three differentially expr

SUBMITTER: Wang X 

PROVIDER: S-EPMC12516497 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature