Genome-wide association study of susceptibility to acute respiratory distress syndrome.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a severe inflammatory process of the lung, often due to sepsis, and poses significant mortality burden in intensive care units. Here we conducted a genome-wide association study (GWAS) of ARDS to identify genetic risk loci that can help guide the development of new therapeutic options.

Methods

We performed a case-control GWAS in 716 cases with ARDS, mainly associated with severe infections, and 4399 at-risk controls from three independent studies. Results were meta-analysed across the three studies, with significance set at p < 5 × 10^-8. Suggestive associations were declared for variants exhibiting consistent direction of effects, likely to replicate and nominal significance (p < 0.05) in all three studies.

SUBMITTER: Guillen-Guio B 

PROVIDER: S-EPMC12516505 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature