Colistin and Oxyclozanide co-loaded PLGA nano-microspheres to reverse colistin resistance can effectively treat colistin-resistant <i>Escherichia coli</i> infections.

ABSTRACT: Colistin (COL) is widely recognized as the last line of defense for treating MDR-negative bacterial infections, but currently, bacteria have a very serious resistance to COL. The combination of antibacterial drugs and adjuvant drugs can reverse drug resistance, enhance antibacterial activity, and improve therapeutic effects. It is currently regarded as a new safe and effective strategy for controlling drug resistance. In this study, we found that the combination of Oxyclozanide (OXY) and colistin can effectively reverse colistin resistance. For multiple colistin resistant Escherichia coli (E. coli) strains, COL-OXY-PLGA @MS significantly reduced the MIC of COL monotherapy (8 < MIC<64) by 40-160 times. The prepared COL-OXY-PLGA@MS had particle sizes of 140-160 nm, PDI of 0.03-

SUBMITTER: Li SH 

PROVIDER: S-EPMC12516539 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature