Macropinocytosis fuels osteoclast differentiation in bone-related diseases.

ABSTRACT:

Objective

Multinucleated osteoclasts are the principal specialised cells responsible for bone resorption, but osteoclastogenesis, the formation of osteoclasts, entails substantial nutrient and bioenergetic demands. Macropinocytosis is an efficient pathway for nutrient scavenging in metabolically active cells; however, the interplay among metabolic state, osteoclast differentiation and macropinocytosis in bone-related diseases remains poorly understood.

Methods

In this study, osteoclast differentiation was induced using murine bone marrow-derived macrophages and RAW 264.7 cells to investigate the role of macropinocytosis in metabolic regulation. Lipopolysaccharide (LPS) was applied to mimic inflammatory conditions in vitro to assess the influence of macropinocytosis on both m

SUBMITTER: Gu M 

PROVIDER: S-EPMC12516540 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature