FDG-PET brain glucose hypometabolism predicts Alzheimer's disease progression pathways in cognitively normal adults: A longitudinal competing risks modeling.

ABSTRACT:

Introduction

Alzheimer's disease progression follows distinct pathways in cognitively normal individuals: direct conversion to dementia versus sequential decline through mild cognitive impairment (MCI). The metabolic determinants of pathway selection remain unclear, limiting personalized intervention strategies.

Methods

We analyzed 1136 cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative with baseline fluorodeoxyglucose positron emission tomography (FDG-PET) and longitudinal outcomes over ten years. Competing risks regression modeled pathway-specific transitions, while multinomial logistic regression predicted pathway membership using brain glucose metabolism. Cross-validation assessed pathway classification accuracy across temporal splits.

SUBMITTER: Alhasan MS 

PROVIDER: S-EPMC12516547 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature