EBF2 regulates cardiolipin and phosphatidylethanolamine remodeling and mitochondrial dynamics in brown fat.

ABSTRACT: Mitochondria are fundamental to energy homeostasis and undergo dynamic changes in brown and beige fat. Mitochondrial dysfunctions impair thermogenic capacity and cause obesity-associated metabolic diseases. The phospholipid composition is crucial for maintaining mitochondrial function and fission-fusion processes. Here, we described early B-cell factor 2 (EBF2), a transcription factor pivotal for brown adipose tissue (BAT) development and function that regulates the integrity of mitochondrial membrane composition, function, and dynamics in brown adipocytes. Strikingly, Myf5^Cre-driven targeted deletion of Ebf2 in BAT drastically reduces cardiolipin and phosphatidylethanolamine abundance and alters acyl chain remodeling of major phospholipids. BAT mitochondria of Ebf2-KO neonates

SUBMITTER: Rajakumari S 

PROVIDER: S-EPMC12516562 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature