Non-tobacco nicotine dependence increases risk of complications following lumbar spine decompression and fusion.

ABSTRACT:

Background

Non-tobacco nicotine products (eg, e-cigarettes, nicotine pouches) are increasingly used by cigarette smokers and prior nonsmokers. While the detrimental effects of cigarette dependence (CD) on healing and surgical recovery are well documented, the impact of non-tobacco nicotine dependence (NTND) on outcomes after lumbar spine surgery remains poorly characterized.

Methods

We conducted a retrospective cohort study using the TriNetX database. Patients undergoing lumbar spine decompression and fusion were divided into 3 cohorts: NTND, CD, and controls (no documented nicotine dependence). Propensity score matching was performed 1:1 based on demographic and clinical characteristics. Complication rates were assessed at 90 days and 3 years postoperatively. Outcomes inclu

SUBMITTER: Spitzer C 

PROVIDER: S-EPMC12516565 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature