Argyrophilic grain disease: epidemiology and association with cognitive decline and parkinsonism.

ABSTRACT: Argyrophilic grain disease is an age-related disorder characterized by the presence of argyrophilic grains. Argyrophilic grain disease has a sequential distribution pattern that begins in the ambient gyrus (Saito Stage I), spreads to the medial temporal lobe (Saito Stage II) and reaches the basal forebrain and cingulate gyrus (Saito Stage III). A strong association with cognitive decline, especially in cases of Saito Stage III argyrophilic grain disease, has also been reported. The main clinical feature includes cognitive decline characterized by memory disturbance, although conflicting results have been reported. Recent studies suggest an association with parkinsonism. To clarify the association between argyrophilic grain disease, cognitive decline and parkinsonism, we performed a clinico

SUBMITTER: Arakawa A 

PROVIDER: S-EPMC12516700 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature