<i>Lithospermum erythrorhizon</i> extract alleviates immunosuppression via MAPK signaling pathway.

ABSTRACT:

Introduction

Lithospermum erythrorhizon extract (LEE), rich in shikonin and its derivatives, has been traditionally valued for anti-inflammatory and wound-healing properties.

Objective

This study aimed to investigate the immunoprotective effects and underlying mechanisms of LEE in a rat model of dexamethasone-induced immunosuppression.

Methods

One hundred SPF Sprague-Dawley rats were randomized into control, model, and LEE treatment groups (10, 20, 40 mg/kg). Immunosuppression was induced with dexamethasone (7.5 mg/kg, i.p.) for 7 days, followed by oral LEE for 21 days. Body weight, food consumption, hematology, and serum biochemistry were assessed. Immunomodulatory effects were evaluated via cytokine profiles, immunoglobulin and complement levels, lymphocyte s

SUBMITTER: Chi X 

PROVIDER: S-EPMC12516705 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature