Global, Regional, and National Time Trends in Mortality for Ischemic Heart Disease, 1990-2019: An Age-Period-Cohort Analysis for the Global Burden of Disease 2019 Study.

ABSTRACT:

Background

Ischemic heart disease (IHD) is the leading cause of mortality and disability worldwide. This study aimed to investigate global trends in IHD mortality across 204 countries and territories over the past 30 years and explore the influence of age, period, birth, and cohort effects on mortality.

Methods

IHD mortality data were retrieved from the Global Burden of Disease (GBD) 2019 study. Temporal trends in the number of deaths, all-age mortality rates, and age-standardized mortality rates were assessed across countries grouped by sociodemographic index (SDI) quintiles. To quantify changes over time, we fitted age-period-cohort (APC) models and derived overall annual percentage changes (net drift) and age-specific annual percentage changes (local drift). The APC model

SUBMITTER: An X 

PROVIDER: S-EPMC12516774 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature