Associations between metabolic dysfunction-associated fatty liver disease and carotid and femoral atherosclerosis: a population-based cross-sectional study.

ABSTRACT:

Background

The associations between metabolic dysfunction-associated fatty liver disease (MAFLD) and its subtypes (diabetes mellitus [DM]-MAFLD, overweight [OW]-MAFLD, and lean MAFLD) with carotid and femoral atherosclerosis are not well understood in the Chinese population.

Methods

This prospective study included participants from southeast China aged between 35-75 years. MAFLD and its subtypes, bilateral carotid and femoral intima-media thickness (CIMT, FIMT, and IMT), plaque (CP, FP, and Plaque), and atherosclerosis (CAS, FAS, and AS), were assessed using ultrasound imaging. Multivariate logistic regression analysis was used to evaluate these associations through odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).

Results

A total of 5392 parti

SUBMITTER: Li Z 

PROVIDER: S-EPMC12516836 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature