Unraveling the causality between carpal tunnel syndrome and trigger finger through genetic instrumental variables.

ABSTRACT:

Objective

Carpal tunnel syndrome (CTS) and trigger finger (TF) are the two most common non-traumatic connective tissue disorders of the hands. These conditions often manifest concurrently in certain patients; however, the mechanisms underlying this phenotypic association remain inadequately understood. In this study, we aimed to systematically investigate the causal relationship between CTS and TF using a large sample size and advanced methods.

Method

In this study, comprehensive summary-level data on CTS and TF from genome-wide association studies (GWAS) were collected. The causal relationship between CTS and TF was investigated using two-sample Mendelian randomization (MR). Sensitivity analyses were conducted to evaluate the robustness of MR findings. Furthermore, multivar

SUBMITTER: Huang J 

PROVIDER: S-EPMC12516840 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature