Prevalence and clinical impact of Vitamin A Deficiency (VAD) in critically ill children with sepsis.

ABSTRACT:

Background

Data on vitamin A deficiency (VAD) among critically ill pediatric patients with sepsis and its impact remain limited. This study aimed to determine the prevalence of VAD in septic children and evaluate its association with clinical outcomes.

Methods

This prospective cohort included 180 children with sepsis admitted to the Pediatric Intensive Care Unit (PICU) of Benha University Hospital, and 40 healthy controls. Using ELISA, serum vitamin A (VA) levels were measured upon admission. Clinical parameters, including the Pediatric Risk of Mortality (PRISM) scores, sepsis progression, ventilation duration, PICU stay, and mortality were assessed. Multivariate regression evaluated the relationship between VAD and sepsis severity.

Results

VAD was significantly more

SUBMITTER: El-Rebigi AM 

PROVIDER: S-EPMC12516869 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature