How do recurrent malaria infections occur in clinical cohorts: a mathematical modelling study to support study planning.

ABSTRACT:

Background

Recurrent events of infectious diseases are common and the subject of analyses in many clinical studies. A proper understanding of disease occurrence over time within a cohort provides a basis for study planning and sample size estimation. This study mathematically describes the recurrence of malaria in a malaria-naïve cohort and highlights the necessary assumptions to inform study planning.

Methods

To represent different disease transmission scenarios, five mathematical models with different levels of complexity were constructed to mimic possible real-life scenarios. Model A represents the simplest model with constant infection risk, Model B includes protection due to treatment and reduced individual susceptibility after each infection, Model C shows preventive e

SUBMITTER: Krumkamp R 

PROVIDER: S-EPMC12516898 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature