Adipose mesenchymal stem cell-derived exosomes rescue mitochondrial function through SIRT1 to improve diabetic wound healing.

ABSTRACT:

Background

Diabetic wounds represent the most common type of chronic wounds. Persistent inflammation and elevated oxidative stress are hallmark features of chronic wounds, where macrophage phenotypic polarization playing a critical role in the healing process. Adipose-derived mesenchymal stem cell exosomes (ADSC-exos) have shown promising therapeutic effects in the treatment of diabetic wounds by modulating macrophage function. This study aims to elucidate the specific downstream regulatory mechanisms through both in vitro and in vivo investigations.

Methods

A streptozotocin-induced diabetic mouse model and high glucose-stimulated RAW 264.7 macrophages were utilized to mimic diabetic microenvironments. Wound tissues were collected from patients with diabetic fo

SUBMITTER: Bai X 

PROVIDER: S-EPMC12516946 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature