<i><b>PCSK9</b></i> <b>genetic variants, carotid atherosclerosis and vascular remodelling</b>.

ABSTRACT:

Background

Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein cholesterol (LDL-C) and reduced cardiovascular disease (CVD) risk, while gain-of-function variants correlate with elevated LDL-C concentrations and increased CVD risk. This study investigated whether genetically determined LDL-C levels, proxied by four PCSK9 genetic variants, influence common carotid artery atherosclerosis.

Methods

The analysis included 3040 European participants (mean age 64.2±5.4 years; 45.8% men) at high cardiovascular risk from the IMPROVE Study, alongside 49 088 individuals of white British ancestry (mean age 55.2±7.6 years

SUBMITTER: Coggi D 

PROVIDER: S-EPMC12517018 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature