Liver fibrosis with persistently normal alanine transaminase levels exhibits a distinct treatment response in MASLD.

ABSTRACT:

Objective

Metabolic dysfunction-associated steatotic liver disease (MASLD) presents considerable variability in disease progression and treatment outcomes. We aimed to determine whether specific patterns of liver inflammatory flares are correlated with distinct treatment responses.

Methods

We conducted an analysis of a well-characterised prospective cohort involving treatment-naïve MASLD patients from January 2015 to November 2023 at The First Affiliated Hospital of Sun Yat-sen University. Participants underwent a standardised 48-week lifestyle modification programme, with follow-up extending through December 2024. Liver fat content (LFC) was assessed using MRI-based proton density fat fraction (MRI-PDFF), whereas liver stiffness measurements (LSMs) were performed using two-

SUBMITTER: Luo L 

PROVIDER: S-EPMC12517019 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature