Selective antitumor activity of Tumor Treating Fields (TTFields) involving molecular factors in cancer cells and tumor microenvironment.

ABSTRACT: The local application of low-intensity electric fields at intermediate frequencies (Tumor Treating Fields - TTFields) has emerged as an effective anticancer treatment in conjunction with chemotherapy and immunotherapy for several solid tumors. Despite this progress, the phenotypic and genetic determinants underlying tumor sensitivity to TTFields remain largely unexplored, representing a critical gap in our understanding. This review provides a comprehensive analysis of preclinical and translational studies describing the cellular factors that influence the anticancer properties of TTFields. An overview of recent omics studies on the complex cellular and molecular processes initiated by TTFields has revealed important mechanisms of action that warrant further investigation for their therape

SUBMITTER: Fuso Nerini I 

PROVIDER: S-EPMC12517075 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature