Engineering macrophage responses through 3D scaffold microarchitecture.

ABSTRACT: Biomaterial implantation in living tissues triggers a physiological response known as foreign body reaction, leading to the recruitment of macrophages, that can polarize either into a pro-inflammatory (M1) or an anti-inflammatory (M2) phenotype. Currently, there is growing interest in tailoring the physical properties of biomaterials to promote efficient tissue regeneration. Tridimensionality can profoundly influence macrophage behaviour; however, there is no clear consensus on the underlying mechanisms. 3D microstructures may play a crucial role in modulating immune cells, promoting anti-inflammatory responses, and supporting effective tissue repair and regeneration. In this study, we designed and fabricated 3D scaffolds with large pores (50 × 50 × 20 μm³) and small pores (15 ×

SUBMITTER: Martinelli C 

PROVIDER: S-EPMC12517081 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature