Exploring electroencephalographic chronic pain biomarkers: a mega-analysis.

ABSTRACT:

Background

Chronic pain is associated with alterations in brain function, offering promising avenues for advancing diagnostic and therapeutic strategies. In particular, these alterations may serve as brain-based biomarkers to support diagnosis, guide treatment decisions and monitor clinical courses of chronic pain.

Methods

Motivated by this potential, this study analysed associations between chronic pain and changes of large-scale brain network function using resting-state electroencephalography (EEG) from 614 individuals with chronic pain, collected by research groups from Australia, Germany, Israel, New Zealand, and the US.

Findings

Employing a discovery-replication approach, we found limited replicability of associations between pain intensity and brain network con

SUBMITTER: Bott FS 

PROVIDER: S-EPMC12517086 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature