DNA methylation mediates the immunosuppressive tumour microenvironment in metastatic endometrial clear cell carcinoma.

ABSTRACT:

Background

Endometrial clear cell carcinoma (ECCC) is a rare and highly aggressive histological subtype of endometrial cancer with marked metastatic potential. The molecular characteristics and underlying mechanisms governing its metastatic behaviour remain poorly understood. This study aimed to delineate molecular distinctions between metastatic (Pm) and non-metastatic (Pn) primary ECCC tumours, elucidate DNA methylation-mediated regulatory mechanisms driving metastasis, and identify potential epigenetic biomarkers and therapeutic targets.

Methods

This multicentre study involved 51 individuals diagnosed with ECCC, leading to the establishment of two independent cohorts: a sequencing cohort (n = 35) for integrated whole-genome methylation and transcriptomic analysis, and a t

SUBMITTER: Jia H 

PROVIDER: S-EPMC12517104 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature