Meta-Analysis: Mortality Trends and Risk Factors in Severe Alcohol-Associated Hepatitis.

ABSTRACT:

Background

Severe alcohol-associated hepatitis (sAH) is a life-threatening condition. Despite advances in clinical management, prognosis remains poor and long-term effectiveness of available therapies is uncertain. We conducted a systematic review and meta-analysis to evaluate short-term mortality (28, 60, and 90-day) trends in sAH over the past five decades.

Methods

We searched PubMed, EMBASE, and Scopus from database inception to February 2024 for studies reporting 28, 60, and 90-day mortality in patients with sAH. Pooled mortality estimates were calculated using a random-effects meta-regression model. We assessed heterogeneity using the I² statistic and explored sources of heterogeneity through subgroup and meta-regression analyses. Separate Bayesian mixed-effe

SUBMITTER: Siddique MR 

PROVIDER: S-EPMC12517119 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature