Spermidine mitigates lipopolysaccharide-induced acute lung injury by enhancing autophagic flux.

ABSTRACT: The primary pathological characteristics of acute lung injury (ALI), comprise the dysfunction of the endothelial barrier, primarily due to the death of pulmonary microvascular endothelial cells (PMVECs), with pyroptosis identified as the principal mechanism underlying lipopolysaccharide (LPS)-induced endothelial cell death. Current research suggests that autophagy suppresses pyroptosis. Spermidine (SPD), an endogenous polyamine, is known for its potent ability to induce autophagy. Nevertheless, the impact of SPD on LPS-induced ALI and PMVEC pyroptosis remains unclear. In the present study, an ALI model was established through an intratracheal injection of LPS. SPD treatment significantly alleviated LPS-induced lung injury in mice and reduced caspase-1 activation and gasdermin D N-terminal

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12517128 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature