Engineering micelles with hydrophilic-lipophilic balance to overcome intestinal barrier for oral therapeutic application.

ABSTRACT: The primary challenge in developing oral nanocarriers lies in achieving a balance between mucus penetration and cellular endocytosis. Overcoming this dilemma tends to require multiple surface properties on design of nanocarriers, but it is not favorable to clinical translation due to the complex preparation procedure and availability of commercial material. Herein, we innovatively constructed a hydrophilic-lipophilic balanced micelles only composed of poly (lactic acid)-b-poly (ethylene glycol) (PLA-PEG) or poly (lactic acid)-b-poly (carboxybetaine) (PLA-PCB) for oral delivery. The hydrophobic core of micelles was reasonably exposed by adjusting the size and the molar mass ratio of hydrophilic to hydrophobic segment of polymer, and significantly enhanced cellular internalization were obser

SUBMITTER: Liu K 

PROVIDER: S-EPMC12517172 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature