<i>Runx1</i> overexpression induces early onset of intervertebral disc degeneration.

ABSTRACT: Intervertebral disc degeneration (IDD) is closely associated with aging. Although the Runt-related transcription factor 1 (RUNX1) is well known for its role in skeletal development and other musculoskeletal related diseases such as osteoarthritis, its involvement in IDD pathogenesis remains elusive. In this study, we examined the function of Runx1 specifically in the nucleus pulposus (NP) in vivo. To achieve NP-specific postnatal overexpression of Runx1, we crossed Krt19^CreERT mice with Rosa26-Runx1 transgenic mice previously generated in our laboratory. Mice with NP specific Runx1 overexpression displayed early onset and progressive disc degeneration beginning at 5 months of age. This was characterized by a phenotypic shif

SUBMITTER: Fukunaga T 

PROVIDER: S-EPMC12517211 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature