Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles.

ABSTRACT: TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism.

SUBMITTER: Ruano JL 

PROVIDER: S-EPMC12517213 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature