Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields.

ABSTRACT:

Background

Intrabuccal administration of amplitude-modulated 27.12 MHz radiofrequency electromagnetic fields (AM RF EMF) resulting in the systemic delivery of low and safe levels of AM RF EMF has shown activity in several forms of cancer.

Methods

Glioblastoma (GB) cell lines were exposed to GB-specific AM RF EMF (GBMF) three hours per day at a level of exposure identical to patients during treatment. Cellular assays and agnostic genomic approaches were used to characterize the mechanism-of-action. One patient with therapy refractory GB received compassionate use treatment with GBMF as well as a second patient with refractory oligodendroglioma.

Results

Treatment with GBMF inhibited the proliferation of several GB cell lines. CACNA1H mediates the effect of GBMF. GBMF mo

SUBMITTER: Jimenez H 

PROVIDER: S-EPMC12517218 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature