Gastric microbiota-specific signatures in adults with obesity and Helicobacter pylori-negative gastritis.

ABSTRACT:

Background

The role of the gastric microbiome in the pathophysiology of gastritis beyond Helicobacter pylori (HP) infection is poorly understood and has remained unexplored in patients with obesity. The aim of this study was to analyse gastric mucosa-associated microbiota in patients with obesity and nonatrophic chronic gastritis in the absence of HP infection or history of HP eradication.

Methods

This was a case-control study conducted at Virgen de la Victoria University Hospital in Malaga, performed in patients with severe obesity (body mass index ≥40 kg/m²) undergoing sleeve gastrectomy, without HP infection and no history of HP eradication. Gastric biopsy specimens were collected at surgery and were analysed by 16S rRNA sequencing. Participants were divided in

SUBMITTER: Martinez-Montoro JI 

PROVIDER: S-EPMC12517247 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature