Parvovirus B19-associated myocarditis in children: A systematic review of clinical features, management and outcomes.

ABSTRACT:

Background

Parvovirus B19 (PVB19) has emerged as a relevant etiologic agent of paediatric myocarditis, particularly during recent epidemiological surges in Europe and the United States. Despite increasing recognition, current knowledge remains fragmented, and standardised diagnostic and therapeutic strategies are lacking.

Methods

We conducted a systematic review of the literature up to May 2025, including 40 studies encompassing 53 individual case reports, 107 patients from registry-based cohorts, and 4 tissue-based investigations.

Results

Clinical presentation was frequently fulminant, with cardiogenic shock, severe left ventricular dysfunction, and need for mechanical circulatory support in up to 47% of cases. Mortality rates ranged from 10% to 30%, with heart trans

SUBMITTER: Veronese G 

PROVIDER: S-EPMC12517251 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature