Mapping Macrophage Diversity in Coats' Disease: A Lipid-Associated Subset in the Pathogenesis of Exudative Retinopathy.

ABSTRACT:

Purpose

Coats' disease is a retinal vasculopathy characterized by retinal telangiectasia, exudation, and retinal detachment. Lipid exudates serve as crucial biomarkers for the assessment and prediction of disease progression. However, the pathophysiological mechanisms driving exudation remain inadequately understood. This study aimed to investigate the cellular and molecular mechanisms underlying the pathogenesis of Coats' disease.

Methods

Single-cell suspensions of epiretinal membrane and vitreous samples were collected from a patient with Coats' disease, and corresponding vitreous and epiretinal membrane samples from four patients with proliferative vitreoretinopathy were used as controls. The samples were analyzed by single-cell RNA sequencing using Seurat, Slingshot, hdW

SUBMITTER: Xie R 

PROVIDER: S-EPMC12517359 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature