Biomechanical Relationships Between the Aqueous Veins and Perilimbal Sclera During Intraocular Pressure Regulation.

ABSTRACT:

Purpose

A major assumption of microinvasive glaucoma surgeries (MIGS) is that effective intraocular pressure (IOP) reduction can be achieved by enhancing aqueous humor (AH) outflow into the aqueous veins. However, this IOP outcome is not predictable in part due to lack of knowledge concerning the role of tissue biomechanics on AH outflow through the distal aqueous veins within the perilimbal sclera (PLS). The purpose of this study is to investigate the biomechanical response of the aqueous veins and the PLS and their interaction during IOP.

Methods

Optical resolution photoacoustic microscopy were implemented to capture the 3D deformations of the aqueous veins and in the surrounding PLS during aqueous outflow in porcine and human whole globes. Partial trabeculotomy was perfor

SUBMITTER: Ni L 

PROVIDER: S-EPMC12517370 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature