Impaired Vagal Tone Function-Based Regulation of Systemic Inflammation in Patients With Neovascular Age-Related Macular Degeneration.

ABSTRACT:

Purpose

The purpose of this study was to investigate vagal nerve function and correlation to CD4+ T-cell population in patients with neovascular age-related macular degeneration (nvAMD) and healthy individuals.

Methods

This study is a prospective case-control study including 36 patients with nvAMD and 40 healthy individuals. We measured the proxy of vagus nerve activity, the resting heart rate variability (HRV). Freshly sampled venous blood was prepared to measure CD4+ T-cell populations regulated by the vagal tone (regulatory T cells [Tregs], recently thymic emigrant Tregs, naïve Tregs, and effector memory T cells).

Results

Compared with healthy individuals, patients with nvAMD had significantly lower HRV (low frequency/high frequency [LF/HR] ratio, P = 0.037 and sta

SUBMITTER: Molbech CR 

PROVIDER: S-EPMC12517380 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature