The mechanism of dynamic steady states in lamellipodia.

ABSTRACT: Lamellipodia are quasi-two-dimensional actin projections formed on the leading edge of the cell, playing an important role in sensing surrounding mechanical environments by forming focal adhesions. A branched actin network in the lamellipodia exhibits a stable, yet dynamic steady state characterized by a retrograde flow, which is attributed to a balance between network assembly at the leading edge and disassembly at the rear. Although the molecular players and architecture of the lamellipodia have been investigated extensively during recent decades, it still remains elusive how the dynamic steady state with continuous retrograde flow is achieved and robustly maintained. Using an agent-based computational model, we probed how physical interactions between subcellular components in the lamel

SUBMITTER: Kim JH 

PROVIDER: S-EPMC12517506 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature