Interplay of human macrophage response and natural resistance of infection by L. (V.) panamensis to pentavalent antimony.

ABSTRACT: Macrophages are the principal host cells of Leishmania spp. in human infection and play a critical role in controlling infection and enabling parasite survival and persistence. Nevertheless, understanding of drug resistance in leishmaniasis has primarily focused on the parasite. This investigation provides evidence of the significant differential macrophage response to ex vivo infection with clinical strains of L. (V.) panamensis naturally resistant (zymodeme 2.3/zym 2.3) or sensitive (zymodeme 2.2/zym 2.2) to antimonial drug, and the distinct effect of this drug on the activation of macrophages. Transcriptome analysis of infected monocyte-derived macrophages from healthy donors revealed significant interferon and cytokine signaling in response to zym 2.3 strains compared to zym 2.2 strain

SUBMITTER: Fernandez OL 

PROVIDER: S-EPMC12517518 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature