KIF18A induces the EMT process of hepatoma cells through the 5-LOX-dependent arachidonic acid pathway.

ABSTRACT: The high morbidity and mortality rates of liver cancer prompt us to constantly explore new therapeutic strategies. The arachidonic acid metabolism-related pathways play a crucial regulatory role in the growth, invasion and angiogenesis of liver cancer cells, thus becoming a key entry point in liver cancer research. This study aims to explore the role of KIF18A in the epithelial-mesenchymal transition (EMT) of liver cancer cells through the 5-LOX-dependent arachidonic acid pathway, and to construct a prognostic model to predict the prognostic risk of patients with hepatocellular carcinoma (HCC). Through bioinformatics techniques, we screened out prognosis genes related to arachidonic acid metabolism in HCC and constructed a prognostic model of HCC. We evaluated and verified the model, and a

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12517525 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature