Muscle insulin resistance in type 1 diabetes with coronary artery disease.

ABSTRACT:

Aims/hypothesis

The risk for coronary artery disease (CAD) is substantially increased in type 1 diabetes and it has been postulated that insulin resistance may contribute to this risk. The current study measured insulin resistance in type 1 diabetes with vs without CAD and with a focus upon skeletal muscle, to test the hypothesis that insulin resistance is more severe in participants who have type 1 diabetes and CAD. Additionally, in type 1 diabetes, we examined the hypothesis that insulin resistance is more severe in soleus (an oxidative type muscle) vs tibialis anterior (a more glycolytic type of muscle).

Methods

Insulin resistance was measured in participants with type 1 diabetes with (n = 9, CAD+) and without CAD (n = 10, CAD-) using euglycaemic insulin infusions combine

SUBMITTER: Williams KV 

PROVIDER: S-EPMC12517547 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature