Pre-ICU statin therapy reduces 28-day mortality in sepsis-associated brain dysfunction: a propensity-matched analysis of potential neuroprotective mechanisms.

ABSTRACT:

Background

Sepsis-associated brain dysfunction (SABD) is a severe complication of sepsis characterized by acute cognitive impairment and altered mental status, contributing to increased morbidity and mortality in intensive care units (ICUs). The pathophysiology involves neuroinflammation, oxidative stress, and blood-brain barrier disruption. Despite evidence suggesting potential anti-inflammatory and antioxidative properties of statins, their neuroprotective effects in SABD patients remain poorly characterized.

Methods

This retrospective cohort study utilized the MIMIC-IV database (version 3.1), including adult ICU patients meeting Sepsis-3.0 criteria and diagnosed with SABD, defined as Glasgow Coma Scale (GCS) score <15 or presence of delirium. Patients with preexisting neu

SUBMITTER: Yu L 

PROVIDER: S-EPMC12517583 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature