Adhering to the Barcelona Clinic Liver Cancer Disease Staging and Treatment Algorithm: Disease Burden and Cost of Illness of Hepatocellular Carcinoma in Portugal.

ABSTRACT:

Objectives

The aim of this study was to assess disease burden and cost of illness of hepatocellular carcinoma (HCC) in Portugal, assuming full adherence to the treatment algorithm associated to the Barcelona Clinic Liver Cancer (BCLC) system.

Methods

An individual-level, continuous-time, state-transition model was used to simulate the progression of HCC patients through the BCLC disease stages. Health state transition rates were derived from the published literature. An expert panel provided further information on Portuguese epidemiology and clinical practice, including treatments and other healthcare resources utilization at each disease stage. Unit costs for health resources were collected from national public sources. HCC associated costs and outcomes were estimated over

SUBMITTER: Picado N 

PROVIDER: S-EPMC12517673 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature