Synchronous ensembles of hippocampal CA1 pyramidal neurons during novel exploration.

ABSTRACT: Synchronous neuronal ensembles play a pivotal role in the consolidation of long-term memory in the hippocampus. However, their organization during the acquisition of spatial memory remains less clear. In this study, we used neuronal population voltage imaging to investigate the synchronization patterns of mice CA1 pyramidal neuronal ensembles during the exploration of a new environment, a critical phase for spatial memory acquisition. We found synchronous ensembles comprising approximately 40% of CA1 pyramidal neurons, firing simultaneously in brief windows (~25ms) during immobility and locomotion in novel exploration. Notably, these synchronous ensembles were not associated with contralateral ripple oscillations but were instead phase-locked to theta waves recorded in the contralateral CA

SUBMITTER: Chen EL 

PROVIDER: S-EPMC12517686 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature