KDM5 demethylases suppress R-loop-mediated 'viral mimicry' and DNA damage in breast cancer cells.

ABSTRACT: Tumors with low expression of interferon-stimulated genes (ISG) and antigen presentation (AP) genes respond relatively poorly to current immunotherapies. One of the early hallmarks of cancer is DNA hypomethylation in genomic repeat regions that can result in the expression of normally silenced endogenous 'viral' elements. Such epigenetic changes have the potential to augment anti-tumor immune responses as well as reduce tumor cell fitness through the generation of aberrant nucleic acid species (NAS) and consequent activation of NAS-sensing pathways. Therefore, tumor evolution should favor additional selective events that suppress NAS generation, possibly yielding specific therapeutic vulnerabilities. Here, we show that the lysine demethylase 5 (KDM5) family of epigenetic regulatory enzymes

SUBMITTER: Lau L 

PROVIDER: S-EPMC12517688 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature