Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.

ABSTRACT: The resting primate brain is traversed by spontaneous functional connectivity patterns that show striking differences between conscious and unconscious states. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, can improve signs of consciousness in disorders of consciousness (DOCs); however, can it influence both conscious and unconscious dynamic functional connectivity? We investigated the modulatory effect of prefrontal cortex (PFC) tDCS on brain dynamics in awake and anesthetized non-human primates using functional MRI. In awake macaques receiving either anodal or cathodal tDCS, we found that cathodal stimulation robustly disrupted the repertoire of functional connectivity patterns, increased structure-function correlation (SFC), decreased Shannon

SUBMITTER: Hoffner G 

PROVIDER: S-EPMC12517689 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature