Associations of insulin resistance surrogate with resistant hypertension and the severity of hypertension in the chronic kidney disease population.

ABSTRACT:

Background

Extensive research has explored the relationship between the triglyceride-glucose (TyG) index and hypertension, yet the associations of the TyG index with resistant hypertension and the severity of hypertension in the chronic kidney disease (CKD) population remain unclear.

Methods

We analyzed data from 3944 CKD participants in the NHANES survey (1999-2020). Binary and ordered logistic regression analyses assessed the TyG index's impact on hypertension categories (uncontrolled, resistant, and refractory hypertension) and severity.

Results

Higher TyG index quartiles were significantly associated with higher odds of hypertension categories after adjustments for covariates. Specifically, the odds ratios (ORs) for the highest quartile were 1.68 (1.27-2.22) for u

SUBMITTER: Bao K 

PROVIDER: S-EPMC12517730 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature