Plasmon-Enhanced Fluorescence Paper Lateral Flow Strip for Point-of-Care Testing of SARS-CoV-2 Antigens.

ABSTRACT: Currently commercial colorimetric paper lateral flow immunoassays exhibit insufficient limit of detection (LOD) and limited clinical sensitivity toward the detection of SARS-CoV-2 antigens, which causes a high false negative rate. To mitigate this issue, a new plasmon-enhanced fluorescence probe was developed for paper lateral flow strips (PLFSs). The probe is made of a sandwich-structured Ag-core@silica@dye@silica-shell nanoparticle in which fluorescent dyes are sandwiched between the plasmonic Ag core and the silica outer shell, and the separation distance between the Ag core and the dye molecules is controlled by the silica space layer. At the optimal thickness of the silica space layer, plasmons can amplify fluorescence signals via the Purcell effect. The PLFS with the optimized plasmo

SUBMITTER: Hang Y 

PROVIDER: S-EPMC12517765 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature