Exploring the potential causal association between oral microbiota and heart failure using Mendelian randomization in an East Asian population.

ABSTRACT: Growing evidence suggests that the gut microbiota is closely associated with the risk of developing heart failure (HF). However, the potential impact of oral microbiota on HF has received far less attention. Using instrumental variable from the latest genome-wide association study data in East Asian populations, we evaluated the genetic predisposition to HF associated with 455 salivary microbiota and 540 tongue microbiota. The HF dataset was derived from Biobank Japan, including 9413 HF cases and 203,040 controls. The inverse-variance weighted method was used to assess potential causal associations between oral microbiota and HF. Robustness of the results was confirmed through MR-Egger regression intercept test and MR-PRESSO global test. Inverse-variance weighted analysis identified 33 ton

SUBMITTER: Peng S 

PROVIDER: S-EPMC12517784 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature