Early versus late oral anticoagulation after mild to moderate AIS in AF patients: Insights from real-world data.

ABSTRACT: The optimal timing for initiating oral anticoagulation in patients with atrial fibrillation (AF) following acute ischemic stroke (AIS) remains uncertain in specific subgroups and real-world settings. This study evaluates the association between early (≤2 days) versus later (>2 days) oral anticoagulation initiation and short-term clinical outcomes in patients with AF and mild to moderate AIS. We conducted a retrospective cohort study using the TriNetX global research network. Adult patients (≥18 years) diagnosed with both AF and AIS (National Institutes of Health Stroke Scale 0-15) between January 2010 and February 2025 were included. Patients were categorized into early and later initiation groups based on treatment start time. The primary outcome was a 30-day composite of tissue plasminog

SUBMITTER: Wu JY 

PROVIDER: S-EPMC12517804 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature