Plasma proteins and the risk of inflammatory bowel diseases: A two-sample Mendelian randomization study.

ABSTRACT: Dysregulated plasma proteins are therapeutic targets for inflammatory bowel disease (IBD), which is a major global health burden. There is limited causal evidence for these associations. Mendelian randomization (MR) was applied to assess the genetic links between plasma proteins and IBD risk. Genetic instruments for 3282 plasma protein phenotypes were derived from genome-wide association studies (GWAS). Summary statistics from IBD GWAS (overall, Crohn disease [CD] and ulcerative colitis [UC]) were analyzed via inverse-variance weighted (IVW) regression, estimating odds ratios (OR) and 95% confidence intervals (CI). Four proteins showed associations with overall IBD risk: erythrocyte band 7 integral membrane protein (OR = 0.84, 95% CI = 0.77-0.90), Interleukin-1 receptor-like 1 (IL1RL1; OR 

SUBMITTER: Jiao Z 

PROVIDER: S-EPMC12517818 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature