Immune cells in diabetic retinopathy: A Mendelian randomization study.

ABSTRACT: The role of immune cells in diabetic retinopathy (DR) is unclear. This study aims to assess the causal effect of various immune cells on DR by Mendelian randomization (MR). Immune cell datasets were acquired from European Bioinformatics Institute, and a DR dataset was acquired in FinnGen. Single nucleotide polymorphisms were screened stepwise according to the assumptions of association, independence, and exclusivity. Inverse variance weighted was used as the main method for MR analysis. MR-Egger was used to assess the horizontal pleiotropy of the results. Cochran Q and leave-one-out methods were respectively used for heterogeneity and sensitivity of the results. MR analysis identified 11 immune cell phenotypes associated with an increased genetic susceptibility to DR: T cell related phenot

SUBMITTER: Jiang P 

PROVIDER: S-EPMC12517842 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature