COPD-associated proteins as biomarkers and drug targets: Insights from genetic and proteomic analyses.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a major global health burden with significant morbidity and mortality. Identifying circulating protein biomarkers may help understand COPD pathogenesis and develop novel therapeutic targets. We conducted a 2-sample Mendelian randomization (MR) analysis to assess the causal relationship between circulating proteins (cis-pQTLs) and COPD. Co-localization analysis confirmed shared genetic variants, while tissue-specific and pathway analyses provided insights into the biological roles of key proteins. Protein-protein interaction network analysis was conducted, and the impact of lifestyle factors on COPD-related proteins was also evaluated. Mendelian randomization analysis identified 18 proteins in the Decode dataset and 8 in the UK Biobank Pharmac

SUBMITTER: Lin X 

PROVIDER: S-EPMC12517858 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature