Causal effects between mitochondrial functional proteins and sepsis: A Mendelian randomization study.

ABSTRACT: More and more studies have shown that mitochondria play a key role in the pathogenesis of sepsis. However, the pathogenesis of sepsis is complex, and there are ethical and implementation challenges in conducting large-scale randomized controlled trials. Mendelian randomization (MR) analysis selects genetic variants as instrumental variables based on genome-wide association studies (GWAS) to infer causal relationships, which can avoid traditional confounding factors. The data of this study were sourced from the IEU OpenGWAS database. The GWAS summary data of 66 mitochondrial functional proteins (MPs) and 5 types of sepsis and their subtypes were included. The "TwoSampleMR" R package was used for analysis. Five methods, including the inverse variance weighted (IVW) method, were used for caus

SUBMITTER: Zheng B 

PROVIDER: S-EPMC12517865 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature