Exploring the relationship between atorvastatin and rosuvastatin use and respiratory, thoracic, and mediastinal disorders: A retrospective study.

ABSTRACT: This study aimed to comprehensively evaluate the risk of respiratory, thoracic and mediastinal disorders associated with atorvastatin and rosuvastatin use. We conducted a retrospective pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database from Q1 2014 to Q1 2023. Disproportionality analysis was performed to quantify the risk of respiratory, thoracic and mediastinal disorders, using the reporting odds ratio (ROR), confidence interval (CI), information component (IC), and its lower 95% credibility interval (IC025). We also assessed the time to onset of these adverse events. We identified a total of 15,676 reports of respiratory, thoracic and mediastinal disorders linked to statins were identified. Atorvastatin (ROR = 2.05, 95% CI: 2.02-2.08, IC = 0.96, IC025 =

SUBMITTER: Tan T 

PROVIDER: S-EPMC12517866 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature